Rheumatoid arthritis treatment tnf blockers

However, when individual agents were compared, some were more likely than others to result in this level of disease control.There have been no head-to-head trials of biologic treatment in RA and it is difficult to compare results from different trials due to differences in patient groups involved (patients vary from trial to trial in severity and duration of disease).The introduction of biologics is the latest advance in the treatment of RA, and one that has significantly broadened and improved the drug treatment options for patients.These state that treatment with biologics As stated above, the decision of whether to use a biologic to treat RA is a complex one that depends on several factors, including how active your disease is, whether you have already tried other conventional treatments that are considered the first option in RA treatment, and cost considerations.In contrast to conventional DMARD treatments, which act on the immune system as a whole, biologics are engineered to target specific molecules on immune system cells, such as receptors on T- or B-cells, to block the actions of these cells and, thereby, dampen the out-of-control inflammatory process that characterizes an autoimmune disease like RA.There were no significant differences between individual biologics in terms of rates of ACR50 response.Biologics used in RA are proteins that come from human genes.As RA becomes established and disease control becomes more difficult to achieve, the case for using biologics becomes stronger on both a clinical and economic basis.One review considered five different biologics, infliximab, rituximab, etanercept, adalimumab, and abatacept.Toclizumab (Actemra) is an IL-6 inhibitor, rituximab (Rituxan) is a B-cell inhibitor, abatacept (Orencia) is a T-cell inhibitor, anakinra (Kineret) is a IL-1 inhibitor, and, the newest biologic in RA tofacitinib (Xeljanz) is a JAK inhibitor.Given the high cost of biologic treatments, at present these drugs typically make sense in early RA only if other treatments fail to control the disease.However, unlike conventional DMARDs, newer biologics specifically target certain key immune system cells and chemicals (specifically cytokines) that play an important role in the autoimmune response involved in RA.

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